digimon 1st edition booster box Universe: Appli Monsters each with 12 cards featuring iconic Digimon and tamers Digimon Card Game - Gift

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Partner this card with Sanguine Bond, and you have a nigh-unstoppable chain reaction that will drain your opponents of all their remaining life

Overall, there are plenty of ways to disrupt the opponent's hand, and some of them are more permanent, but Iono is the most efficient way of doing so

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This can really rack up over multiple turns, especially if you have more than one down

Legendary Six Samurai - Enishi would also take care of problem cards by returning them to the hand as a Quick Effect.