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Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG4) deuterium-labeled-halide NCCOCCOCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95%

SKU: 17776920439

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Description

NCCOCCOCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

Sulfo-Cy5 offers similar optical characteristics but with enhanced water solubility and reduced non-specific interactions

Product Name 2-chloro-4-fluoro-N-(methy-d3)laniline Synonyms CAS Number n/a Related CAS Molecular Formula C7H7ClFN Molecular Weight 162

Product Name Azide-Lys(m-PEG4)-Val-Cit-OH Synonyms CAS Number Related CAS Molecular Formula C27H50N8O10 Molecular Weight 646

Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG4) deuterium-labeled-halide NCCOCCOCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX

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